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., 2000). This sparing of CB1 receptors following peripheral nerve harm could point out a potential therapeutic advantage of cannabinoids over opioids while in the therapy of neuropathic discomfort. This speculation is further supported by a modern analyze (Mao et al

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Following this, unilateral L5 spinal nerve ligation was performed. 7 days later, sensory thresholds have been reassessed and the development of allodynia to chilly and mechanical stimuli and hyperalgesia to your noxious thermal stimulus confirmed.

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